Abstract
A GDP-azasugar conjugate was synthesized starting from an enzymatically obtained phosphorylated azasugar. It inhibits human fucosyltransferase V at micromolar concentrations, which is discussed in terms of transition state analogy.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites / physiology
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Carbohydrate Metabolism
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Carbohydrates / chemistry*
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Fucosyltransferases / antagonists & inhibitors*
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Guanosine Diphosphate / analogs & derivatives
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Guanosine Diphosphate / chemistry*
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Guanosine Diphosphate / pharmacology*
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Inhibitory Concentration 50
Substances
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Carbohydrates
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Guanosine Diphosphate
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Fucosyltransferases
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fucosyltransferase V